A tactical planning model for a job shop with unreliable work stations and capacity constraints

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1988.Bibliography: leaf 54.by Shoichiro Mihara.M.S

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes

Advanced EO System for the Japanese Small Satellite ASNARO

There are growing demands for the earth observation satellite system also from the newly developing countries. Inorder to meet these demands, the Ministry of Economy, Trade and Industry (METI), is promoting ASNARO projectand the Japanese first small EO satellite system is currently under the manufacturing stage. ASNARO spacecraft,with its total mass of approx. 500kg, will observe GSD of better than 50cm and will represent unprecedented as asmall satellite. The target of ASNARO spacecraft is to achieve as good performance as large scale EO satellites, andthe ground segment will further enhance operation performances. This paper introduces the satellite operationsystem and utilization of the ASNARO’s resources to the maximum extent and to provide operational performancesand services competitive to that of the large scale EO satellites

Analysis of Atomic Oxygen Fluence Distribution on Satellite Surface

The atomic oxygen (AO) in low Earth orbit erodes spacecraft materials. Since the organic materials are significantly damaged by AO, we must evaluate the erosion effects during satellite missions before launch. The first step in evaluating the erosion effect due to AO is to determine the distribution of AO fluence and/or flux on the entire satellite surface during the satellite mission. The AO fluence on the satellite surface is different for different parts of the satellite surface because the ram surface receives AO changes according to the satellite attitude in orbit. Therefore, AO fluence must be estimated by considering the satellite attitude, shape, ram direction and AO density in orbit. However, there are no studies in which the AO fluence distribution is estimated for the entire satellite surface. In addition, there is no tool to analyze AO fluence distribution on the satellite surface. Thus, in this study, we construct an AO fluence distribution analysis tool and estimate the AO fluence distribution on the entire satellite surface

Analysis of Atomic Oxygen Fluence Distribution on Satellite Surface

The atomic oxygen (AO) in low Earth orbit erodes spacecraft materials. Since the organic materials are significantly damaged by AO, we must evaluate the erosion effects during satellite missions before launch. The first step in evaluating the erosion effect due to AO is to determine the distribution of AO fluence and/or flux on the entire satellite surface during the satellite mission. The AO fluence on the satellite surface is different for different parts of the satellite surface because the ram surface receives AO changes according to the satellite attitude in orbit. Therefore, AO fluence must be estimated by considering the satellite attitude, shape, ram direction and AO density in orbit. However, there are no studies in which the AO fluence distribution is estimated for the entire satellite surface. In addition, there is no tool to analyze AO fluence distribution on the satellite surface. Thus, in this study, we construct an AO fluence distribution analysis tool and estimate the AO fluence distribution on the entire satellite surface

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes